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EP 22 | Reposição Hormonal: riscos de câncer? Quando começar? Mitos e o que realmente sabemos...

Hoje eu vou falar da minha posição sobre os riscos de reposição, se estrogênio dá câncer, o que as evidências atuais mostram e porque talvez precisemos aprender a pensar sobre saúde sem tanta passionalidade e com muito mais conhecimento.

Porque será que o tema reposição hormonal na mulher é tão controverso e gera tanta reatividade, resistência entre as próprias mulheres?

Porque você acha que não precisar te faz superior? Às vezes é preciso muito mais do que somente força de vontade para nos sentirmos melhor.

Pesquisas:

Estrogen Matters: Why Taking Hormones in Menopause Can Improve Women’s Well-Being and Lengthen Their Lives – Without Raising the Risk of Breast Cancer: Bluming, Avrum, Tavris, Carol: 9780316481205: Amazon.com: Books

Op-Ed: Once and for all: Hormone replacement is good for women

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women’s Health Initiative Randomized Controlled Trial | Breast Cancer | JAMA | JAMA Network

WHI 2003

https://www.ncbi.nlm.nih.gov/pubmed/12824205   

1991 article saying ‘time for action, not debate’ that if women took estrogen, they would live longer and healthier: Uncertainty about Postmenopausal Estrogen — Time for Action, Not Debate   

1-in-4 (25%) women die of heart disease: Women and Heart Disease Fact Sheet  

The lifetime risk of dying from breast cancer is 1-in-38 (2.6%): Lifetime Risk of Developing or Dying From Cancer

Women have a 1-in-8 (12%) risk of getting breast cancer: U.S. Breast Cancer Statistics | (breastcancer.org) 

Report that progesterone together with estrogen, nullified the risk of uterine cancer: Prevention of endometrial cancer with progestogens. 

The two arms of the Women’s Health Initiative: [41:45]

  1. Dietary modification | (whi.org)
  2. Hormone therapy | (whi.org)

Article explaining how the WHI manipulated stats to show a 25% increase in breast cancer with HRT: Menopausal hormone therapy and breast cancer: what is the evidence from randomized trials? 

2013 JAMA paper responsible for the common belief that HRT causes a 25% increase in breast cancer: Menopausal Hormone Therapy and Health Outcomes During the Intervention and Extended Poststopping Phases of the Women’s Health Initiative Randomized Trials (Manson et al., 2013) [57:15]

2015 JAMA paper responsible for the common belief that HRT causes a 25% increase in breast cancer: Breast Cancer After Use of Estrogen Plus Progestin and Estrogen Alone, Analyses of Data From 2 Women’s Health Initiative Randomized Clinical Trials